Sharmila is a professional playback singer, rapper and lyricist in South India. Other than singing, she is also known for rapping. Sharmila has rapped songs like Alaika Alaika from the movie Thuppakki starring Tamil actor Ilayathalapathy Vijay and actress Kajal Agarwal. Sharmila has also rapped a song from the Tamil movie Theeya Vela Seiyanum Kumaru starring Siddharth and Hansika Motwani. Sharmila is said to select only peppy songs to perform and not explore sentimental and melody songs. When asked for the reason behind this preference, she says that she feels fast paced songs are more suitable to her voice and that maybe the reason for the music directors also to suggest mostly pop songs to her.

Even while giving live performances on stage, Sharmila prefers to sing live and energetic songs compared to soulful, soothing music as she does not like to stand at a spot and sing. Sharmila was introduced as a singer, lyricist, and rapper in a single song by Tamil music director Vijay Anthony. She feels very blessed and privileged to have gotten this opportunity from an established composer. Sharmila is always grateful to him for introducing her in the field. Her debut song was Kadhalikka Pen Oruthi for the movie Vedi starring actors Vishal and Sameera Reddy in lead roles directed by Prabhu Deva which released in the year 2011. This song was sung by Andrea Jeremiah, Emcee Jezs and Naresh Iyer and Sharmila wrote and sung the rap part. Her debut song became a spark in her career as it led to offers of various other songs especially having recognized her talent as a rapper.

Sharmila has then rapped in the song Mascara in the movie Salim with Vijay Anthony as the lead actor and music director which released in the year 2014. Sharmila has worked in many songs with the music director Harris Jayaraj. Some of their collaborations include Tamil movies like Nanban, Ko, 7 am Arivu, Oru Kal Oru Kannadi, Yennai Arindhal, and many more. She has also performed in many of his live concerts. These live concerts gave her a big opening as it gave Sharmila the opportunity to sing with many great established musicians. She was part of Harris Jayaraj's world tour, and she got the chance to sing songs sung by other singers too. Sharmila had given a demo to Harris Jayaraj and was waiting for a call from him for about two years. When she was about to give up hope, she suddenly received a call from him. After that, she started doing a lot of harmonies and backup singing.