He is a Malayalam actor and producer, famous for his comedy and drama roles. He was initially a theater artist, writer, and started Kalidasa Visual Magic to produce plays. His first play was Chayanmukhi, directed by Prasanth Narayan, which say him essay Keechaka’s role. He completed his schooling from Infant Jesus School Kollam and BSc from Sree Narayana College, Kollam and also has an LLB degree from Government Law College, Thiruvananthapuram. He married twice. His first wife was actor Saritha with whom he has two sons Shravan and Tejas, who are pursuing their academics from Dubai and New Zealand respectively. His second wife is
, dancer, whom he married in 2013.
He started his movie career with the film Baloon in the year 1982. His movies Odaruthammava Aalariyam in 1984,
the year after, Shyama and Adiverukal in 1986, earned his consecutive accolades. 1989 was a turning point in his career. With the role of Gopalakrishnan, a stock character his stardom created was a young, comical and deceitful man who went on an illegal path as the society and life pressurized him to tread that path, leaving him with no other option, a product of the state, in the movie, Ramji Rav Speaking.
Starting from this, Mukesh Babu became a box office favorite and moved on as a bankable star with blockbusters like Harihar Nagar and Godfather in 1990 and 91 respectively. After this, there was a string of comic movies in the late 90s likeInnathe Programme in 1991 and four years later Sipayi Lahala then the hitKalyana Kacheri in 19997 and Mattupetti Machan the year after. His more noticeable roles during that time wereSiddique's Hitler in 1996 and Friends, made three years later. He and Priyadarshan together worked in Kakkakuyil in 2001. The year 2000 was the second twist in Mukesh’s tale. He began taking up numerous stock character roles, for example- Chronic Bachelor, the very famous Sethurama Iyer CBI and Innathe Chintha Vishayam (2008). 2007 saw Mukesh, the producer. Sreenivasan and Mukesh Babu together formed their very own production house Lumiere Film Company whose first film Katha Paryumpol (2007) was a box office hit.
The second one,
(2012) also came to be a great hit. 2009 saw his smashing, pathbreaking comeback with To Harihar Nagar in his immortal role Mahadevan and it became the biggest commercial success of his career. This led to one blockbuster after another with Mukesh starrers- Ghost House Inn and Mummy & Me both in the same year 2010, Oru Marubhoomi Kadha and Nadakame Ulakam, two big hits of 2011, Lucky Star in 2013Mannar Mathai Speaking 2 in 2014 and Adi Kapyare Kootamaniand
in the next year.