Patricia was born in Chicago in Illinois in the year 1968. She is known to be the offspring of the actor Lewis Arquette and Brenda Olivia "Mardi" who was known for involvement in arts and his works on therapy. Her family lived in the rural area of Bentonville, Virginia for a while, on a commune when they became very poor. She mentioned that her father often consumed alcohol, and her mother was very abusive. At the age of 20, she was in a relationship with a musician named Paul Rossi. She gave birth to Enzo Rossi, on 3rd January 1989.She got married to
in 1995 who was her co-actor in her movie Bringing Out the Dead in the year 1999. However, they got separated nine months after their marriage but did not let the public know about the same. In 2000, Nicholas applied for divorce. Later, by withdrawing the petition, they tried to work for reconciliation but in Nov 2000, she applied for divorce. She got engaged with
in 2002. They had a daughter named Harlow Olivia Calliope Jane, who was born on February 20, 2003. She later applied for divorce again, but they reconciled soon, and she withdrew the petition in 2009 in the month of July. But they agreed for the joint charge of their daughter when they finally got divorced due to irreconcilable differences on August13, 2010. Her first role was a pregnant teenager character in the film named "
". In 1988, she played in the Far North. In the early 1990s, she played low budget characters, and most of her films were independent. She became famous for the character of Alabama Whitman, which is a free-spirited and also a caring prostitute role in Tony Scott's " True Romance" in 1993. Although few critics tried to deter it, the movie was moderately successful. She then acted in "Betrayed by Love", a television film, in 1994 in which she was a girlfriend of
, under the direction of
. She played in "Beyond Rangoon" in the year 1995. At the Film Festival of Cannes in France in 1995, the film became very familiar. She acted in 3 movies in 1996 namely, "Flirting with Disaster", " The Secret Angel" and "Infinity". She took a gap of 3 years after the routine response of Tiptoes.
She appeared in her next film in 2006 namely, "Fast Food Nation" which was under the direction of Richard Linklater. Throughout the three years, the lady was on the work of Boyhood, which got on to the screen after eight years in the year 2014. Fast Food Nation was her second partnership with Linklater, which received important positive remarks. The film was awarded three upon four by Peter Travers of the biweekly magazine, Rolling Stone. In Jan 2005, she made her first shift to TV. She won Emmy Awards for her outstanding performance as a lead actress in the year 2005 along with many other nominations. She did not act in any film till 2012. In the year 2013, she acted in the film, the true crime drama Electric Slide, but it did not get on to the screens yet. Boyhood was released in 2014. It was a project which was shot for about 12 years. The director of the movie was Richard Linlater, who marked his 2nd association with Patricia. He role was a mother who brings up both her kids almost all alone with very less assistance of father, the role acted by
. The film was universally appreciated. But many of them criticized it as the "landmark film". She won the Critics' Choice, BAFTA, Academy, Independent Spirit, Golden Globe and for being a Best Supporting Actress, she also won SAG Awards. Arquette is known for her charity work. She formed an NPO named GiveLove with Rosetta Millington, her friend which supported ecological sanitation, community development projects, composting, etc. at Haiti after the earthquake in 2010. She also took part in many other NPOs like Eracism Foundation, The Art of Elysium, The Heart Truth and Libby Ross Foundation; She is also known for the small screen profitable work for many dogs and also cats which were homeless. When she lost her mother due to breast cancer in the year 1997, she worked to make people aware about such diseases. She was also the speaker of the Lee National Denim Day, which accumulates dollars in millions for research and also education on breast cancer. She also became a member of the team of the welding students at Miami in Florida to provide housing in Haiti to the displaced people in April 2010.