Brahmanandam was born on 1st February 1956. He was the seventh son to Kanneganti Nagalingachari and Kannaganti Lakshmi Narsamma. He completed his high schooling from a high school at Sattenapalle. He later pursued his intermediate and graduation from D.N.R College, Bhimavaram. He completed his post graduation in Telugu literature from Andhra University. Before becoming an actor, Brahmanandam had worked as a lecturer in Atthilli for nine years.
Brahmanandam is considered as one of the most versatile Indian comic actors, noted particularly for his comic expressions. He has gone ahead to receive many accolades in the world. In the year 2007, he was in the Guinness World Record for appearing in the highest number of films that is over 1000 movies. The government of India honored him with Padma Shri Award in the year 2009. Brahmanandam was awarded the Best Actor in a comic role in the year 2011 at The Hyderabad Times Film Awards.
In the year 2012 in Dookudu, he was voted the Best Comedian in the Cinemaa Awards. The same year he was also awarded the Best Comedian in the SIIMA Awards. He went ahead to clinch the Best Actor in a Comic Role Award in the TOIFA awards ceremony. Surely Brahmanandam deserves all this because of his natural talent and hard work in the acting industry. Brahmanandam is married to Lakshmi Kanneganti, and he is blessed with two children, namely; Raja Goutham and Siddharth.