Shilpa Kadam gained popularity with Indian audiences by her role as Dr. Simran in Sanjivani-A Medical Boon. This television serial was a hit and aired from 2002 to 2005 with two seasons on Star Plus channel. The protagonist played by Shilpa Kadam was loved by the Indian audiences and gained a lot of recognition. In the show, she was playing the role of the wife of Dr.Rahul Mehra (
in real life). Mihir Mishra was also her boyfriend then; their love story started from the sets of Sanjivani itself. But, later on, they broke up their long term relationship due to unknown reasons.
The actor also shot for a commercial ad with superstar
Shah Rukh Khan
. She told the media that she is a big SRK fan and was blown away by his dimples. She had done some dance steps with SRK in a Sunfeast commercial. Her life has been quite difficult after Sanjivani as things didn't turn up as expected and her numerous projects such as ‘Naam Gum Jayega’ and 'Koi Jaane Na' failed.