Usha comes from a normal middle-class family that lived in Chennai. She spent her life in that city. Her origins lie in Varkkala, Kerela. Her parents were, father Mothi and mother Sudeshini. She started working at a tender age. Her parents separated and by the age of 19, her mother died. As her acting career began, she married a Malayalam director, N Shakaran Nair. A decade later, they had a son. Ever since she continues to live in Chennai. She has two younger sisters; Sangeetha Raman and Rajini. She married N. Shankaran Nair (Malayali movie director) and had a boy child named Vishnu Shankaran Nair.

Usha Rani has been working in a movie since her childhood. She was a lead Malayali actress in 1970’s and 1980’s. She continued to work until the early 2000’s. Usha Rani has worked in some Malayalam movie, but she hasn’t restricted her arena. She continued to work in some Tamil, Kanada, Telegu and even tried her hands on some Hindi movies. Some of her successful movies include Thenkashipattanam, Ekalavyan, Hitler and Amma Ammayiyamma.