Sayali Salunkhe is a Marathi film and television actress. She was born in Mumbai, Maharashtra, to Suchita and Santosh. Sayali was passionate about acting, which made her take up the acting diploma from "SRM Film School" in Pune. SRM is an acting and film-making school nurturing talents to shine in their respective fields. They not only train students but give them practical experience by offering opportunities to act in the industry. Sayali, soon after completing her course, stepped into the modeling field. She has acted in several tv commercials and advertisements. Sayali modeled for several photoshoots in Mumbai for famous photographers.

She was keen on modelling, so she participated in the pageant "Maharashtra Times Shravan Queen" in 2017. "MT Shravan Queen" is a popular contest conducted for the young girls of Maharashtra. The girls who make it through the auditions are selected and groomed for the final show. Sayali was the winner of the 2017 edition of the contest. Winning the Beauty Pagaent was a huge breakthrough in her career. Soon after her win, she stepped into the television industry. She marked her debut through the Marathi serial "Chatriwali" as the main character's sister. This show aired in Star Pravah in the year 2018. Sayali later went on to act in the serial “Sukh Manje Nakki Kay Asta” in Star Pravah. She portrayed the prominent role "Jothikah" in this Marathi family drama.

Sayali also acted in the Hindi series "Mehndi Hai Rachnewaali" and depicted the character of Kirti Rao. Sayali made her film debut with the Marathi film "Eghan." This film portrayed the day-to-day struggles of farmers and their difficult life. She plays the lead character in this Marathi film. Sayali has also acted in a Marathi web series aired on the "Sony Liv" named "Full Tight." This web series was a short 7 episode show with a family setting based on how parents deal with their kids. Full tight is a family entertainer packed with humor.