Mandakini Amte is a renowned doctor and social worker. Coming from Maharashtra, she completed her MBBS from Nagpur. She pursued a post-graduation degree in Anesthesia from Government Medical College, Nagpur. During her post-graduation, she met her future husband,
. In December 1974, the couple got married. Later on, they had three children. Her father-in-law, Baba Amte, was a great social activist. After their marriage, they started doing social work and moved to Hemalkasa village, Gadchiroli, Maharashtra.
In 1973, Lok Biradari Prakalp (The People's Brotherhood) founded an initiative for tribal communities in the most remote forests of the Gadchiroli district. In 1976, they established a residential school for tribal children. Greet and Guy Barthelemy (a French couple) called them the Schweitzer couple of India. In 1995, impressed by their dedication, the Principality of Monaco issued a postage stamp to honour their selfless work. In 2008, the couple was lauded for their efforts and awarded with Ramon Magsaysay for Community leadership. In 2010-11, the Sheikh Hamdan International Award for Volunteers in Humanitarian Medical gave the couple an award for their contributions.