Manisha Yadav was born and brought up in Bhopal, the state capital of Madhya Pradesh. She completed her graduation from there and then joined the Anupam Kher's Actors Prepares academy in Mumbai. After completing this course, she rushed for the glamour world and got her first break in TV serials in Imtihan, which was made for Doordarshan. She has also worked in Shapath in Life Ok and CID in the Sony channel.
Though Manisha was working in Hindi TV serials for quite some time in the past, unfortunately, her performances did not receive the recognition they deserved. She came into the limelight for her performance in '
,' one of the highest TRPs in the recent past. In this serial, she is playing the role of Salima Begum, one of the emperor's wives, apart from the more popular Jodha Begum played by
and Rukaiya Begum played by
. This wife of Akbar was also considered to be one of the wisest women.
When she was offered this role, she did a lot of research work and utilized her education to bring authenticity to the character portrayed by her. Manisha Yadav has also done item songs in the Hindi movie 'Makad Jaal' and Marathi film' Fultoo Dhamal.'
Manisha Yadav was married and had a son. She had been posting pictures of her son and called him her life and heart. July 2021, her son celebrated his 1st birthday, and Manisha shared some video clips taken on his birthday and expressed her happiness. The actress suffered a brain hemorrhage and died on 1st October 2021. It was a shocking death, and her friends and colleagues couldn't believe it. After the super hit serial, Jodha Akbar on Zee TV stopped the actresses, who played the prominent roles were in contact through a WhatsApp group, Mughals. Manisha's death news was out on that WhatsApp group, and that's how her co-stars were informed. Everyone is concerned about Manisha's one-year-old son.