Manisha Yadav was born and brought up in Bhopal, the state capital of Madhya Pradesh. She completed her graduation from there and then joined the Anupam Kher's Actors Prepares academy in Mumbai. After completion of this course, she rushed for the glamour world and got her first break in TV serials in Imtihan which was made for Doordarshan. She has also worked in Shapath in Life Ok and CID in Sony channel.
Though Manisha was working in Hindi TV serials for quite some time in the past but unfortunately her performances did not receive the recognition they deserved. She came into the limelight for her performance in currently running serial of Zee TV '
' which has one of the highest TRPs in the recent past. In this serial she is playing the role of Salima Begum , one of the wives of the emperor apart from more popular Jodha Begum played by Paridhi Sharma and Rukaiya Begum played by
. This wife of Akbar was also considered to be one of the wisest women.
When she was offered this role, she did a lot of research work and utilized her education to bring authenticity to the character portrayed by her.
Manisha Yyadav has also done item songs in Hindi movie 'Makad Jaal' and Marathi film' Fultoo Dhamal' which are yet to be released.