Mann Kee Awaaz Pratigya 2 is a Star Bharat serial that started airing on 15th March 2021. Mann Kee Awaaz Pratigya 2 is the sequel to the hits series, Mann Kee Awaaz Pratigya, aired in 2009 on Star Plus. Mann Kee Awaaz Pratigya 2 is directed by Neeraj Pandey. Shanti Bhushan is the writer. The story is by Pearl Grey, Lakshmi Jayakumar and Anshula Mathur and the screenplay is by Pearl Grey. Paresh Shah composed the music. Rajan Shahi produced the serial under the banner, Director's Kut Productions. Sanjay Mishra cranked the camera and Sameer Gandhi edited the serial. The series has the star cast of Pooja Gor, Arhaan Behll, Anupam Shyam, Bhumika Gurung, Asmita Sharma, Sachal Tyagi, Aalika Sheikh, Parvati Sehgal, Dhruvin Sanghvi, Prachi Thakur, Araham Sawant, Athar Siddiqui, Ashish Kapoor, Naved Raza and Chetan Hansraj.
Pratigya is a public prosecutor now. The Thakurs, who were once involved in criminal activities, had given up everything and started following a normal lifestyle. Balwant’s son gets hit by a car driven by Garv, who was forcefully locked in the car by Samar and Girish. Krishna knows the truth but hides it from Pratigya. Balwant’s son dies in this accident and he wanted to find out the person who killed his son. So, he takes this to Pratigya. Krishna, who doesn’t want Garv to get stuck with this case, destroys the evidence that might make Garv face legal punishment. Later, Pratigya comes to know the truth and assure that it will be treated as an accident and not a murder. So, she brings Garv to court. The judge also stated what Pratigya said, but he punishes Krishna for destroying the evidence. So, Krishna gets arrested.
Pratigya’s health started deteriorating and the doctor's report stated that she has cancer. In a series of incidents, Krishna gets married to Meera. Komal knows that Sumitra has given poison to Pratigya to separate her permanently from Krishna. Aadarsh, who loved Komal, misunderstands her and marries Pratigya. Later, Krishna comes to know that Pratigya was poisoned. In an accident, Pratigya goes into a coma and Krishna loses his memory. After a year, Pratigya gains consciousness and takes steps to regain Krishna’s memory. Will they rejoin? The rest of the story deals with it.